Kidney

Exercise, Bone Disease and Chronic Kidney Disease

by Patricia Gordon, R.N., Ph.D

Disturbances in mineral and bone metabolism occur early in the course of chronic kidney disease (CKD). Without prevention or treatment these disturbances progress to renal osteodystrophy encompassing varying combinations and degrees of high- and low-turnover bone disorders.

Although a broad body of literature indicates that load-bearing exercise has favorable effects on bone metabolism in the adult and aged skeleton [1, 2], there are no studies on the impact of exercise on bone in chronic or end stage renal disease (ESRD). However, much of what is known regarding the effects of exercise on bone, particularly in osteoporosis, may be helpful in the preservation of bone strength in these populations. This may be especially relevant due to the contribution of age-associated osteoporosis as the average age of CKD and ESRD patients increases.

While high impact activity is especially osteogenic [3], moderate intensity walking results in modest increases in lumbar bone mineral density (BMD) [4], indicating that low-impact activities can have a beneficial effect. This is an important consideration for individuals with kidney disease since they are prone to fatigue and generally have low exercise capacity [5]. Read more…

Be the first to comment - What do you think?  Posted by Toton - September 4, 2011 at 10:33 pm

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Kidney Stones: The Video

As you know that I’ve got two-times kidney stones attack within the period of 13 years. That were very much painful; so, I hope you will not experience this kind of kidney disorder.  This time, I’d love to share with you the video regarding the kidney stones.


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2 comments - What do you think?  Posted by JavaHealth - December 29, 2010 at 9:31 am

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Maintain Your Kidneys’ Health All the Time

My friend’s son passed away last week at the age of 25 due to renal (kidney) failure. He started undertaking dialysis a year ago. It is a showcase that dialysis is not enough to maintain your kidneys’ normal function.

I got explanation from his family that during his teenage up to his death he had unhealthy lifestyle. As a student, he accustomed to drink instant energy drink and to consume instant noodle almost everyday. As we know that both kind of modern-processed food are rich of artificial food additives, such as MSG and artificial colorings and sweeteners. I hope you could learn from this tragic case: never consume too much food containing artificial food additives.

Many people who have chronic kidney disease don’t know it, because the early signs can be very subtle. It can take many years to go from chronic kidney disease (CKD) to kidney failure. Some people with CKD live out their lives without ever reaching kidney failure.

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1 comment - What do you think?  Posted by JavaHealth - April 24, 2010 at 4:28 pm

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Vitamin C, Cancer, and Kidney Stones, Part II

Vitamin C

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. Unlike most mammals and other animals, humans do not have the ability to make their own vitamin C. Therefore, we must obtain vitamin C through our diet.

Function

Vitamin C is required for the synthesis of collagen, an important structural component of blood vessels, tendons, ligaments, and bone. Vitamin C also plays an important role in the synthesis of the neurotransmitter, norepinephrine. Neurotransmitters are critical to brain function and are known to affect mood. In addition, vitamin C is required for the synthesis of carnitine, a small molecule that is essential for the transport of fat into cellular organelles called mitochondria, where the fat is converted to energy (1). Research also suggests that vitamin C is involved in the metabolism of cholesterol to bile acids, which may have implications for blood cholesterol levels and the incidence of gallstones (2).
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2 comments - What do you think?  Posted by JavaHealth - January 29, 2010 at 11:00 am

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Saturated Fats for the Kidney’s Health

One of the body’s most important organs is the kidney. Properly functioning kidneys are essential for maintaining proper blood volume and composition; for filtering and excreting or saving various chemical metabolites; and for helping to maintain proper blood pressure. Hypertension (high blood pressure) is known to result from improperly functioning kidneys. Research carried out during the last few years indicates that both saturated fat and cholesterol play important roles in maintaining kidney function, as do the omega-3 fatty acids.

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1 comment - What do you think?  Posted by JavaHealth - October 27, 2009 at 11:32 am

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Kidney Stone: You Have to Know It Better

My True Story

I experienced suffering kidney stones two times in my life. The first one I’ve got in 1994 (when I was 28). Suddenly my urine became red and there was pain (renal colic) at waist area. I didn’t want to undertake any surgery to take out nor other measure to destroy the stone. I chose the moderate way, i.e.  to pass  the stone out of my body through urinary tract by drinking plenty of water and with the help from specific medicines formulated to ease the stone pass out of my body through  the urinary tract. Four month later, the stone with size of  one inch went out while I was urinating.

The second kidney stone attacked me 13 years later, in 2007. I got two times severe pain (renal colic)  around waist area (so pain that I felt like I would die). Based on the first experience,   I decided only applying the natural method of therapy in order to make the stone out of my body. Even though at  that time I didn’t know exactly what kind of therapy should be. I would like to tell the story  of the natural healing I’ve carried out to overcome the second time kidney stone, but  in the next special article.
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4 comments - What do you think?  Posted by JavaHealth - September 29, 2009 at 5:48 pm

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Really Healthy? Drink Plenty of Water

Drinking water is so important for good health. When you were a kid in school, you learned that each molecule of water is made up of two hydrogen atoms and one oxygen atom. You may also have learned that it was great fun to fill up your squirt guns with water, at least until the principal caught you. What you may not have learned, however, was how much water you needed in order to be a healthy human being.

Why You Need to Drink Water

Your body is estimated to be about 60% to 70% water. Blood is mostly water, and your muscles, lungs, and brain all contain a lot of water. Your body needs water to regulate body temperature and to provide the means for nutrients to travel to all your organs. Water also transports oxygen to your cells, removes waste, and protects your joints and organs.

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1 comment - What do you think?  Posted by JavaHealth - September 27, 2009 at 10:10 am

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Recent Advances in the Pathophysiology of Nephrolithiasis

Abstract

Over the past 10 years, major progress has been made in the pathogenesis of uric acid and calcium stones. These advances have led to our further understanding of a pathogenetic link between uric acid nephrolithiasis and the metabolic syndrome, the role of Oxalobacter formigenes in calcium oxalate stone formation, oxalate transport in Slc26a6-null mice, the potential pathogenetic role of Randall’s plaque as a precursor for calcium oxalate nephrolithiasis, and the role of renal tubular crystal retention. With these advances, we may target the development of novel drugs including:

  1. insulin sensitizers;
  2. probiotic therapy with O. formigenes, recombinant enzymes, or engineered bacteria;
  3. treatments that involve the upregulation of intestinal luminal oxalate secretion by increasing anion transporter activity (Slc26a6), luminally active nonabsorbed agents, or oxalate binders; and
  4. drugs that prevent the formation of Randall’s plaque and/or renal tubular crystal adhesions.

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4 comments - What do you think?  Posted by JavaHealth - September 23, 2009 at 9:53 pm

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Calcium Oxalate in Renal Stone Disease

The Terminal Metabolite That Just Won’t Go Away

Summary

The incidence of kidney stone disease, particularly calcium oxalate nephrolithiasis in the US and other countries  has been increasing throughout the past three decades. Biopsy studies show that both calcium oxalate nephrolithiasis and nephrocalcinosis probably occur by different mechanisms in different subsets of patients. Before more-effective medical therapies can be developed for these conditions, we must understand the mechanisms governing the transport and excretion of oxalate and the interactions of the ion in general and renal physiology. Blood oxalate derives from diet, degradation of ascorbate, and production by the liver and erythrocytes. In mammals, oxalate is a terminal metabolite that must be excreted or sequestered. The kidneys are the primary route of excretion and the site of oxalate’s only known function. Oxalate stimulates the uptake of chloride, water, and sodium by the proximal tubule through the exchange of oxalate for sulfate or chloride via the solute carrier SLC26A6. Fecal excretion of oxalate is stimulated by hyperoxalemia in rodents, but no similar phenomenon has been observed in humans. Studies in which rats were treated with C-oxalate have shown that less than 2% of a chronic oxalate load accumulates in the internal organs, plasma, and skeleton. These studies have also demonstrated that there is interindividual variability in the accumulation of oxalate, especially by the kidney. This Review summarizes the transport and function of oxalate in mammalian physiology and the ion’s potential roles in nephrolithiasis and nephrocalcinosis.

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1 comment - What do you think?  Posted by JavaHealth - at 5:51 pm

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